New research reveals that people who discontinue blockbuster GLP-1 drugs like semaglutide or tirzepatide may regain lost weight much more quickly than those who end traditional diet and exercise plans.
Research printed in a major medical journal shows that while obese individuals frequently drop about a fifth of their total mass while on the medication, the mass returns at an average rate of nearly a kilo each month upon discontinuation.
"Individuals using these drugs must be informed of the potential of rapid weight regain when the medication ends," cautioned researcher Dr. Susan Jebb.
This pace of regain means a return to pre-treatment mass in about 18 months.
Weighing Therapies
The study, which examined 37 of studies involving over 9,000 of patients, contrasted the results of these new drugs with conventional dieting.
The team note that individuals who shed pounds through dieting usually have a less rapid weight regain—perhaps 100 grams monthly—once they finish.
Explaining the Fast Rebound
Nutrition scientists suggest the mode of action of the drugs is key to understanding the heightened weight return.
These medications mimic a body's own chemical called GLP-1, which controls hunger.
"Sustained high doses of the hormone concentrations far above than normal might result in the system to generate a reduced amount of its own natural hormone, and could diminish responsiveness to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Stopping of this hormone supplement results in hunger is no longer kept in check, making overeating much more probable."
A Chronic Disease?
Medical guidelines suggest the injections for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
Many experts contend that, due to the significant potential of weight regain, the therapy should be considered ongoing.
This view is supported by pharmaceutical companies, who say that the findings "highlight the long-term character of obesity," akin to managing diseases like high blood pressure.
Patient Experiences
Users who have come off the jabs describe a intense return of appetite.
"I experienced a trigger activating and I was suddenly ravenous," said an individual.
This difficulty is exacerbated if individuals have not adopted permanent dietary or behavioural modifications during treatment.
Growing Interest
Figures suggest that a significant number of people in the UK have used these injections in the last 12 months, with desire being substantial.
- Adoption is greater among females compared to men.
- The middle-aged age group shows the highest level of interest.
- Many obtain the medications through private healthcare rather than the NHS.
In conclusion, experts caution that while the jabs are effective tools for shedding pounds, they are not a permanent cure and long-term success relies on ongoing lifestyle changes.
